Beware of the Undetectable PSA: a Case of Metastatic Urothelial Carcinoma of the Prostate
نویسنده
چکیده
Primary urothelial carcinoma (UC) of the prostate is rare and accounts for only 0.7-2.8% of all prostate cancers. Unlike conventional adenocarcinoma of the prostate, UC does not express prostate-specific antigen (PSA) which can make diagnosis challenging due to both unexpected serum PSA levels and immunohistochemical profiles. We report the case of a 66 year-old man who was eventually diagnosed with primary urothelial carcinoma of the prostate after he presented with lower urinary tract symptoms (LUTS) in the context of an undetectable serum PSA level. This case highlights the potential pitfall of overlooking the significance of an undetectable PSA level and details the manner in which this rare variant of prostate malignancy can present.
منابع مشابه
Beware of Bone Marrow: Incidental Detection and Primary Diagnosis of Solid Tumours in Bone Marrow Aspiration and Biopsies; A Study of 22 Cases
Background & objective: Introduction: First detection of any solid tumour as metastatic deposits in bone marrow directs clinicians to start searching for the primary tumour. Detection of bone marrow metastasis determines the stage of the malignancy, prognosis, mode of treatment, chemotherapeutic response and follow-up in case of relapse. The aim of the current...
متن کاملHigh-Grade Urothelial Carcinoma of Bladder Transforming to Micropapillary Variant on Follow-Up
Micropapillary variant of urothelial carcinoma (UC) of the bladder is an aggressive tumour, comprising 0.6-6% of all UC. It generally presents with high-grade and stage, and has been reported as having a worse prognosis when compared to traditional UC. We report the case of a 58-year-old man who presented with macroscopic haematuria. The patient was diagnosed with high-grade urothelial carcinom...
متن کاملA Case Report of Primary Squamous Cell Cancer of Prostate
The primary squamous cell carcinoma of prostate is a rare tumor that its histogenesis has not been clearly identified. This tumor comprises 0.5 to 1 % of malignant tumors of prostate. In most cases, there exists a severe and atypical metaplasia. The case was a 66 years man that admitted for increased frequency of urination and a burning sensation. In initial examinations, because of the existe...
متن کاملPSA Screening in Prostate Cancer
Introduction: Prostate cancer is one of the most common cancers in Iranian men. PSA(prostate specific antigen) screening is a controversial issue because PSA screening leads to diagnose of patients with low risk prostate cancer who not only do not benefit from treatment but also suffer from complication caused by treatment. On the other hand, without prostate cancer screening, the rate of meta...
متن کاملAssessing the Diagnostic Value of Plasma-Free DNA in Prostate Cancer Screening
Background: Prostate cancer is the second form of cancer among men worldwide. For early cancer detection, we should identify tumors in initial stages before the physical signs become visible. The present study aims to evaluate the diagnostic value of cell-free DNA (cfDNA), its comparison with prostate-specific antigen (PSA) level in prostate cancer screening and also in patients with localized ...
متن کامل